doctors and merck working on novel coronavirus (covid-19) treatment study

Do you have COVID-19?

COVID-19 is an ongoing global pandemic with very limited treatment options. MERCK is working together with researchers to investigate possible treatment options. This trial is being sponsored by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. (“MERCK”). Learn more about this study for COVID-19 positive patients who have not been hospitalized.

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Study Overview

The MK-4482-002 study will test the safety and effectiveness of an investigational antiviral study drug which may reduce symptoms and recovery time for people who tested positive for COVID-19 in the last 5 days. This clinical study will help researchers learn whether the study drug:

What requirements are in place to help protect clinical trial participants?

There are rules in place to help protect the rights, safety, and well-being of people who volunteer for research studies. These rules are put in place to make sure studies follow strict scientific and ethical guidelines. Before a clinical research study can begin, a review board must review the study. This group is called an IRB or institutional review board. An IRB is made up of doctors, scientists, and members of the community.

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Who Can Join?

To participate in the MK-4482-002 study, participants must be 18 years or older and:

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The study doctor and staff can provide you with information about additional requirements for participation.

What are COVID-19 Symptoms?

Below is a list of common COVID-19 signs and symptoms someone may be experiencing if they have COVID-19.

  • Hard to Breathe
  • Tiredness
  • Cough
  • Diarrhea
  • Fever
  • Loss of Smell
  • Vomiting
  • Stuffy or Runny Nose
  • Headache
  • Chills
  • Nausea
  • Sore Throat
  • Loss of Taste
  • Muscle Aches
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What To Expect

This study will have participants involved for about 7 months over 3 trial phases.

Screening Phase

(Up to 48 hours)

To ensure participants qualify, we may do:

  • A Physical Exam
  • An intake of his/her medical history
  • Blood tests

Treatment Phase

(29 Days)

If they qualify and agree to take part, study participants will be put into a group by chance to get either the antiviral study drug or placebo. A placebo looks like the study drug but does not contain any active medicine. Participants will:

  • Take study treatment twice a day for 7 days
  • Have blood tests
  • Have swab tests of nose and/or throat
  • Have Physical Exams
  • Keep diaries of taking his/her study drug and symptoms

During the 29 days in the study, the participant may have some of the following tests:

  • Blood Pressure
  • Checkup
  • Weight
  • Respiratory Rate
  • Blood Test
  • Heart Rate
  • Temperature
  • Nasal/Throat Swab

Follow-up Phase

(After about 6 months)

We'll schedule a virtual call about 6 months after the Treatment Phase to:

  • Provide the study doctor or a member of the study staff with updates on how participants are feeling

Why participate in this study?

A clinical trial is a research study that tries to answer questions about how medicines work in the people who take them. Researchers run studies to test whether an investigational medication is safe and effective. These studies may help doctors find new ways to help prevent, detect, or treat health problems. Information learned from this clinical research study may help other people in the future. Additional care may also be provided for COVID-19 for those participating. This may include:

  • Medical Care
  • Treatment for COVID-19 and related symptoms
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Is this mandatory? Will it cost anything?

Taking part in this study is voluntary and the participant may stop at any time for any reason. In addition, there is no cost for the study drug or study-related care, tests and exams.

United to learn more about COVID-19

If you would like to see if you are eligible to participate, please find a site near you.

Find a site near you

Where can I learn more?

If you're interested in learning more about the MK-4482-002 study, including potential risks and benefits of participation, you can find additional details here.

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